BME Seminar Series: Dr. Eric Sobie, Mount Sinai

Eric Sobie, PhD
Professor of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Senior Associate Dean for Programmatic Development, The Graduate School of Biomedical Sciences

Abstract: 

"Integrating mechanistic modeling, transcriptomic data, and cellular physiology to illuminate susceptibility to drug-induced cardiac adverse events"

Drugs can cause detrimental effects in the cardiovascular system, and such drug-induced adverse events are a major cause of drug attrition and withdrawal. Even drugs known to be dangerous, however, generally cause adverse events in only a small subset of patients. Our understanding of why particular individuals are more susceptible to adverse events remains extremely limited. I will describe work performed in my laboratory to elucidate susceptibility to drug-induced adverse events through a combination of cellular gene expression measurements, mechanistic mathematical modeling, machine learning, and physiological measurements.

Bio:

Eric Sobie is Professor in the Department of Pharmacological Sciences at Icahn School of Medicine at Mount Sinai. He obtained a Bachelors degree in Biomedical Engineering from Duke University, and a PhD, also in Biomedical Engineering, from Johns Hopkins. His research focuses on obtaining new insight into cardiovascular disorders and potential treatments through a combination of physiological experiments and mechanistic mathematical modeling. Areas of particular interest include arrhythmia mechanisms and causes of drug-induced adverse events. In addition to directing a research laboratory, Dr. Sobie currently serves as Senior Associate Dean for Programmatic Development in the Graduate School and directs an NIH-funded training program in systems pharmacology.