You are here

Jun Liu

  • Professor, Biomedical Engineering
  • Professor, Ophthalmology
  • 1080 Carmack Road
    Roomm 260D
    Columbus, OH 43210
  • 614-247-8904

About

Education

  • B.S., Zhejiang University, 1994
  • M.S., Zhejiang University, 1997
  • Ph.D., The Ohio State University, 2002

 

Key Honors and Distinctions

  • Lumley Research Award, College of Engineering, OSU (2012)
  • Lumley Interdisciplinary Research Award, College of Engineering, OSU (2019)

 

RESEARCH AREAS – Liu Lab

  • Biomechanics; Bioimaging; Ocular pathophysiology; Glaucoma;  Optic nerve head biomechanics; Corneal biomechanics; Bioimaging; High-frequency ultrasound; Ultrasound Elastography; Glaucoma; Keratoconus
  • Professor Liu's research focuses on ocular biomechanics and their non-invasive characterization using ultrasound imaging and microelastography. Her long-term goal is to understand biomechanical factors regulating ocular health and disease

 

 

Honors

  • May, 2002

    Business Plan Competition First Prize.

  • September, 1997

    University Fellowship.

  • July, 2020

    Lumley Research Award.

Edited Books

2016

  • 2016. "Corneal Biomechanics: From Theory to Practice." Kugler Publications.

Chapters

2016

  • 2016. "Ocular pulse elastography." In Corneal Biomechanics: From Theory to Practice, edited by Cynthia Roberts and Jun Liu,
  • 2016. "Comparison of porcine and human cornea and sclera mechanical behavior." In Corneal Biomechanics: From Theory to Practice, edited by Cynthia Roberts and Jun Liu,
  • 2016. "Ex vivo mechanical testing of the cornea." In Corneal Biomechanics: From Theory to Practice, edited by Cynthia Roberts and Jun Liu,
  • 2016. "Definitions and concepts." In Corneal Biomechanics: From Theory to Practice, edited by Cynthia Roberts and Jun Liu,

Journal Articles

2020

  • Clayson, K.; Sandwisch, T.; Ma, Y.; Pavlatos, E. et al., 2020, "Corneal Hydration Control during Ex Vivo Experimentation Using Poloxamers.." Curr Eye Res 45, no. 2, 111-117 - 111-117.

2019

  • Ma, Y.; Pavlatos, E.; Clayson, K.; Pan, X. et al., 2019, "Mechanical Deformation of Human Optic Nerve Head and Peripapillary Tissue in Response to Acute IOP Elevation.." Invest Ophthalmol Vis Sci 60, no. 4, 913-920 - 913-920.

2018

  • Pavlatos, E.; Chen, H.; Clayson, K.; Pan, X. et al., 2018, "Imaging Corneal Biomechanical Responses to Ocular Pulse Using High-Frequency Ultrasound.." IEEE Trans Med Imaging 37, no. 2, 663-670 - 663-670.
  • Pavlatos, E.; Ma, Y.; Clayson, K.; Pan, X. et al., 2018, "Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation.." Invest Ophthalmol Vis Sci 59, no. 8, 3779-3788 - 3779-3788.
  • Mallory, A.; Donnelly, B.; Liu, J.; Bahner, D. et al., 2018, "Addressing spatiotemporal distortion of high-speed tissue motion in B-mode ultrasound." Biomedical Physics and Engineering Express 4, no. 5,

2017

  • Clayson, K.; Pan, X.; Pavlatos, E.; Short, R. et al., 2017, "Corneoscleral stiffening increases IOP spike magnitudes during rapid microvolumetric change in the eye.." Exp Eye Res 165, 29-34 - 29-34.

2016

  • JR Palko, HJ Morris, X Pan, CD Harman, KL Koehl, KN Gelatt, CE Plummer, AM Komáromy, J Liu, 2016, "Influence of age on ocular biomechanical properties in a canine glaucoma model with ADAMTS10 mutation." PLoS ONE 11, no. 6, e0156466 - e0156466.
  • Palko, J.R.; Morris, H.J.; Pan, X.; Harman, C.D. et al., 2016, "Influence of Age on Ocular Biomechanical Properties in a Canine Glaucoma Model with ADAMTS10 Mutation.." PLoS One 11, no. 6, e0156466 - e0156466.
  • Cruz Perez, B.; Pavlatos, E.; Morris, H.J.; Chen, H. et al., 2016, "Mapping 3D Strains with Ultrasound Speckle Tracking: Method Validation and Initial Results in Porcine Scleral Inflation.." Ann Biomed Eng 44, no. 7, 2302-2312 - 2302-2312.
  • Boote, C.; Palko, J.R.; Sorensen, T.; Mohammadvali, A. et al., 2016, "Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation.." Mol Vis 22, 503-517 - 503-517.
  • Metzler, K.M.; Roberts, C.J.; Mahmoud, A.M.; Agarwal, G. et al., 2016, "Ex Vivo Transepithelial Collagen Cross-linking in Porcine and Human Corneas Using Human Decorin Core Protein.." J Refract Surg 32, no. 6, 410-417 - 410-417.
  • Pavlatos,Elias; Perez,Benjamin,Cruz; Morris,Hugh,J; Chen,Hong; Palko,Joel,R; Pan,Xueliang; Weber,Paul,A; Hart,Richard,T; Liu,Jun, 2016, "Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking." JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME 138, no. 2, 021015 - 021015.

2015

  • Pijanka, J.K.; Spang, M.T.; Sorensen, T.; Liu, J. et al., 2015, "Depth-dependent changes in collagen organization in the human peripapillary sclera.." PLoS One 10, no. 2, e0118648 - e0118648.
  • Pijanka,Jacek,K; Spang,Martin,T; Sorensen,Thomas; Liu,Jun; Nguyen,Thao,D; Quigley,Harry,A; Boote,Craig, 2015, "Depth-Dependent Changes in Collagen Organization in the Human Peripapillary Sclera." PLOS ONE 10, no. 2, e0118648 - e0118648.

2014

  • Palko, J.R.; Tang, J.; Cruz Perez, B.; Pan, X. et al., 2014, "Spatially heterogeneous corneal mechanical responses before and after riboflavin-ultraviolet-A crosslinking.." J Cataract Refract Surg 40, no. 6, 1021-1031 - 1021-1031.
  • Metzler, K.M.; Mahmoud, A.M.; Liu, J.; Roberts, C.J., 2014, "Deformation response of paired donor corneas to an air puff: intact whole globe versus mounted corneoscleral rim.." J Cataract Refract Surg 40, no. 6, 888-896 - 888-896.
  • K Metzler, A M. Mahmoud, J Liu, CJ Roberts, 2014, "Biomechanical response of paired donor corneas to an air puff: isolated cornea vs intact whole globe." Journal of Cataract and Refractive Surgery 40, no. 6, 888-896 - 888-896.
  • Cruz Perez, B.; Tang, J.; Morris, H.J.; Palko, J.R. et al., 2014, "Biaxial mechanical testing of posterior sclera using high-resolution ultrasound speckle tracking for strain measurements.." J Biomech 47, no. 5, 1151-1156 - 1151-1156.

2013

  • B Cruz Perez, HJ Morris, RT Hart, J Liu, 2013, "Finite element modeling of the viscoelastic responses of the eye during microvolumetric changes." Journal of Biomedical Science and Engineering 6, 29-37 - 29-37.
  • Palko, J.R.; Iwabe, S.; Pan, X.; Agarwal, G. et al., 2013, "Biomechanical properties and correlation with collagen solubility profile in the posterior sclera of canine eyes with an ADAMTS10 mutation.." Invest Ophthalmol Vis Sci 54, no. 4, 2685-2695 - 2685-2695.
  • HJ Morris, J Tang, B Cruz-Perez, X Pan, RT Hart, PA Weber, J Liu, 2013, "Correlation between biomechanical responses of posterior sclera and IOP elevations during micro intraocular volume change." Investigative Ophthalmology and Visual Science 54, no. 12, 7215-7222 - 7215-7222.
  • Morris,Hugh,J; Tang,Junhua; Perez,Benjamin,Cruz; Pan,Xueliang; Hart,Richard,T; Weber,Paul,A; Liu,Jun, 2013, "Correlation Between Biomechanical Responses of Posterior Sclera and IOP Elevations During Micro Intraocular Volume Change." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54, no. 12, 7215-7222 - 7215-7222.
  • Morris, H.J.; Tang, J.; Cruz Perez, B.; Pan, X. et al., 2013, "Correlation between biomechanical responses of posterior sclera and IOP elevations during micro intraocular volume change.." Invest Ophthalmol Vis Sci 54, no. 12, 7215-7222 - 7215-7222.
  • Palko,Joel,R; Iwabe,Simone; Pan,Xueliang; Agarwal,Gunjan; Komaromy,Andras,M; Liu,Jun, 2013, "Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54, no. 4, 2685-2695 - 2685-2695.

2012

  • Ritchey, E.R.; Zelinka, C.P.; Tang, J.; Liu, J. et al., 2012, "The combination of IGF1 and FGF2 and the induction of excessive ocular growth and extreme myopia.." Exp Eye Res 99, 1-16 - 1-16.
  • Tang, J.; Liu, J., 2012, "Ultrasonic measurement of scleral cross-sectional strains during elevations of intraocular pressure: method validation and initial results in posterior porcine sclera.." J Biomech Eng 134, no. 9, 091007 - 091007.
  • Tang, J.; Pan, X.; Weber, P.A.; Liu, J., 2012, "Effect of corneal stiffening on Goldmann applanation tonometry and Tono-Pen measurements in canine eyes.." Invest Ophthalmol Vis Sci 53, no. 3, 1397-1405 - 1397-1405.
  • Ritchey, E.R.; Zelinka, C.; Tang, J.; Liu, J. et al., 2012, "Vision-guided ocular growth in a mutant chicken model with diminished visual acuity.." Exp Eye Res 102, 59-69 - 59-69.
  • Tang,Junhua; Pan,Xueliang; Weber,Paul,A; Liu,Jun, 2012, "Effect of corneal stiffening on goldmann applanation tonometry and tono-pen measurements in canine eyes.." Investigative ophthalmology & visual science 53, no. 3, 1397-1405 - 1397-1405.
  • Ritchey,Eric,R; Zelinka,Christopher,P; Tang,Junhua; Liu,Jun; Fischer,Andy,J, 2012, "The combination of IGF1 and FGF2 and the induction of excessive ocular growth and extreme myopia." EXPERIMENTAL EYE RESEARCH 99, 1-16 - 1-16.
  • ER Ritchey, C Zekinka, J Tang, J Liu, KA Code, S Petersen-Jones, AJ Fischer, 2012, "Vision-guided ocular growth in a mutant chicken model with diminished visual acuity." Experimental Eye Research 102, 59-69 - 59-69.

2011

  • He, X.; Liu, J., 2011, "Correlation of corneal acoustic and elastic properties in a canine eye model.." Invest Ophthalmol Vis Sci 52, no. 2, 731-736 - 731-736.
  • Tang, J.; Pan, X.; Weber, P.A.; Liu, J., 2011, "Corneal modulus and IOP measurements in canine eyes using Goldmann applanation tonometry and Tono-pen.." Invest Ophthalmol Vis Sci 52, no. 11, 7866-7871 - 7866-7871.
  • Tang, J.; Liu, J., 2011, "Variance of speed of sound and correlation with acoustic impedance in canine corneas.." Ultrasound Med Biol 37, no. 10, 1714-1721 - 1714-1721.
  • Palko, J.R.; Pan, X.; Liu, J., 2011, "Dynamic testing of regional viscoelastic behavior of canine sclera.." Exp Eye Res 93, no. 6, 825-832 - 825-832.
  • X Jiang, X Liu, X Gong, F Zhang, R Wu, J Wu, and J Liu, 2011, "Model and experimental analysis of oblique incident ultrasound in a tissue layer using doublet mechanics theory." Journal of the Acoustical Society of America 130, no. 6, 4117-4125 - 4117-4125.
  • X He and J Liu, 2011, "Correlation of corneal acoustic and elastic properties in a canine eye model." Investigative Ophthalmology and Visual Science 2, no. 52, 731-736 - 731-736.
  • J Tang and J Liu, 2011, "Variance of speed of sound and correlation with acoustic impedance in canine corneas." Ultrasound in Medicine and Biology 10, no. 37, 1714-1721 - 1714-1721.
  • J Tang, X Pan, PA Weber, and J Liu, 2011, "Corneal modulus and IOP measurements in canine eyes using Goldmann applanation tonometry and Tonopen." Investigative Ophthalmology and Visual Science 11, no. 52, 7866-7871 - 7866-7871.

2010

  • He, X.; Spoerl, E.; Tang, J.; Liu, J., 2010, "Measurement of corneal changes after collagen crosslinking using a noninvasive ultrasound system.." J Cataract Refract Surg 36, no. 7, 1207-1212 - 1207-1212.
  • X He, E Spoerl, J Tang, and J Liu, 2010, "Measurement of corneal changes after collagen cross-linking by a non-invasive ultrasound system." Journal of Cataract and Refractive Surgery 7, no. 36, 1207-1212 - 1207-1212.

2009

  • X He and J Liu, 2009, "A quantitative ultrasonic spectroscopy method for non-invasive determination of corneal biomechanical properties." Investigative Ophthalmology and Visual Science 11, no. 50, 5148-5154 - 5148-5154.
  • He, X.; Liu, J., 2009, "A quantitative ultrasonic spectroscopy method for noninvasive determination of corneal biomechanical properties.." Invest Ophthalmol Vis Sci 50, no. 11, 5148-5154 - 5148-5154.
  • Liu, J.; He, X., 2009, "Corneal stiffness affects IOP elevation during rapid volume change in the eye.." Invest Ophthalmol Vis Sci 50, no. 5, 2224-2229 - 2224-2229.
  • J Liu and X He, 2009, "Corneal stiffness affects IOP elevation during rapid volume change in the eye." Investigative Ophthalmology and Visual Science 5, no. 50, 2224-2229 - 2224-2229.

2007

  • Liu, J.; He, X.; Pan, X.; Roberts, C.J., 2007, "Ultrasonic model and system for measurement of corneal biomechanical properties and validation on phantoms.." J Biomech 40, no. 5, 1177-1182 - 1177-1182.
  • Liu, J.; Li, J.; Rosol, T.J.; Pan, X. et al., 2007, "Biodegradable nanoparticles for targeted ultrasound imaging of breast cancer cells in vitro.." Phys Med Biol 52, no. 16, 4739-4747 - 4739-4747.

2006

  • J Liu, AL Levine, JS Mattoon, M Yamaguchi, RJ Lee, X Pan, TJ Rosol, 2006, "Nanoparticles as Image Enhancing Agents for Ultrasonography." Physics in Medicine and Biology 51, 2179-2189 - 2179-2189.
  • Liu,Jun; Roberts,Cynthia,J, 2006, "Finite-element simulation of corneal applanation - Reply." JOURNAL OF CATARACT AND REFRACTIVE SURGERY 32, no. 7, 1074-1074 - 1074-1074.
  • Liu, J.; Levine, A.L.; Mattoon, J.S.; Yamaguchi, M. et al., 2006, "Nanoparticles as image enhancing agents for ultrasonography.." Phys Med Biol 51, no. 9, 2179-2189 - 2179-2189.

2005

  • Liu, J.; Roberts, C.J., 2005, "Influence of corneal biomechanical properties on intraocular pressure measurement: quantitative analysis.." J Cataract Refract Surg 31, no. 1, 146-155 - 146-155.
  • J Liu and CJ Roberts, 2005, "Quantitative Analysis of the Influence of Corneal Biomechanical Properties on IOP Measurement." Journal of Cataract and Refractive Surgery 31, no. 1, 146-155 - 146-155.

2004

  • Wu, J.; Layman, C.; Liu, J., 2004, "Wave equations, dispersion relations, and van Hove singularities for applications of doublet mechanics to ultrasound propagation in bio- and nanomaterials.." J Acoust Soc Am 115, no. 2, 893-900 - 893-900.
  • J Wu, C Layman, and J Liu, 2004, "Wave Equations, Dispersion Relations and van Hove Singularities for Applications of Doublet Mechanics to Ultrasound Propagations in Bio-Singularities for Applications of Doublet Mechanics to Ultrasound Propagations in Bio- and Nano-Materials." Journal of Acoustical Society of America 115, no. 2, 893-900 - 893-900.

2003

  • Liu, J.; Ferrari, M., 2003, "A discrete model for the high frequency elastic wave examination on biological tissue." CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES 4, no. 3-4, 421-430 - 421-430.
  • J Liu and M Ferrari, 2003, "A Discrete Model for the High Frequency Elastic Wave Examination on Biological Tissue." Computer Modeling in Engineering and Sciences 4, no. 3&4, 421-430 - 421-430.

2002

  • Liu, J.; Ferrari, M., 2002, "Mechanical spectral signatures of malignant disease? A small-sample, comparative study of continuum vs. nano-biomechanical data analyses.." Dis Markers 18, no. 4, 175-183 - 175-183.
  • J Liu and M Ferrari, 2002, "Mechanical Spectral Signatures of Malignant Disease? A Small-Sample, Comparative Study of Continuum vs. Nano-Biomechanical Data Analyses." Disease Markers 18, no. 4, 175-183 - 175-183.

Unknown

  • C Boote, JR Palko, T Sorensen, A Mohammadvali, A Elsheikh, AM. Komáromy, X Pan and J Liu, "Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation." Molecular Vision
  • KM Metzler, CJ Roberts, AM Mahmoud, G Agarwal, J Liu, "Transepithelial Collagen Crosslinking in Porcine and Human Corneas Using Human Decorin Core Protein." Journal of Refractive Surgery

Presentations

  • 2009, Presented at Small Animal Imaging Center Seminars,
  • "Quantitative Analysis of Corneal Effect on IOP Measurement." 2005, Presented at Ophthalmology Grandrounds,
  • "Nanoparticles as Molecular Imaging Agents for Ultrasound." 2007, Presented at Biophysics Seminar,
  • "Nanoparticles as Molecular Imaging Agents for Ultrasound." 2007, Presented at College of Veterinary Medicine Biomedical Imaging Signature Program,
  • "Corneal Biomechanics and IOP Measurement." 2008, Presented at College of Optometry Graduate Seminar,
  • "Changes in Corneal Stiffness After Riboflavin-UVA Treatment as Measured by Ultrasound." 2008, Presented at International Congress of Corneal Crosslinking,
  • "Targeted Nanoparticles for Ultrasound Imaging." 2006, Presented at Mini-Symposium of the Nanospectroscopy Consortium,
  • "Biomedical Ultrasound and Imaging Laboratory for Disease Diagnosis." 2006, Presented at Biophysics Preceptor Talk,
  • "Ultrasonic Detection Of Changes in Corneal Biomechanical Properties Associated with Hydration Effects." 2007, Presented at International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity,
  • "Detection of Changes in Corneal Biomechanical Properties after Collagen Crosslinking Using a Novel Immersion Ultrasound Technique." 2009, Presented at The American Society of Cataract and Refractive Surgery Symposium: Controversies in Corneal Collagen Crosslinking,
  • Characterization of distributive scleral strains during physiological loadings using high frequency ultrasound radiofrequency analysis. 2012, Presented at International Society for Eye Research,
  • "Corneoscleral Biomechanics and Intraocular Pressure." 2014, Presented at The COBB Rich Lecture at University of Alabama at Birmingham Department of Ophthalmology,
  • "Corneal and Scleral Strains Measured from Ultrasound Speckle Tracking." 2014, Presented at World Congress of Biomechanics,
  • "Ocular Biomechanics: Advances in 3D and in vivo Measurements." 2016, Presented at Devers Eye Institute,
  • "In Vivo Assessment of Ocular Coat Dynamics: Is It Relevant in Glaucoma?." 2016, Presented at Annual Meeting of the American Society of Glaucoma,
  • "3D and in vivo measurements of biomechanics using ultrasound." 2016, Presented at OSU Biophysics Program,
  • "Differentiating mechanical properties of corneal phantoms using an ultrasound method." 2005, Presented at International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity,
  • "Biomechanics in the Health and Disease of the Eye." 2014, Presented at OSU Biophysics Program,
  • "Ocular Pulse Elastography of the Cornea Using High Frequency Ultrasound." 2015, Presented at Asia-Pacific Academy of Ophthalmology Congress,
  • "Viscoelastic Properties of Human Sclera and Influence on Acute IOP Elevation." 2010, Presented at World Congress of Biomechanics,
  • "Correlation between Acoustic Properties and Young’s Modulus in Canine Corneas." 2010, Presented at World Congress of Biomechanics,
  • "Ocular Biomechanics:Clinical Implications and Beyond." 2011, Presented at Ophthalmology Grandrounds,
  • "Characterizing Heterogeneous Tissue Deformation using Ultrasound Speckle Tracking." 2014, Presented at World Congress of Biomechanics,
  • "Biomechanics in the Health and Disease of the Eye." 2015, Presented at OSU College of Optometry,
  • "Nonlinearity of cornea biomechanical properties measured by an ultrasonic system." 2006, Presented at International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity,

Papers in Proceedings

2016

  • ER Pavlatos, X Pan, RT Hart, PA Weber, J Liu "IOP-induced strains in the optic nerve head using ultrasound speckle tracking." in Summer Biomechanics, Bioengineering and Biotransport Conference. (8 2016).

2015

  • ER Pavlatos, B Cruz Perez, HJ Morris, H Chen, RT Hart, J Liu "3D strains in posterior sclera using ultrasound speckle tracking." in Summer Biomechanics, Bioengineering and Biotransport Conference. (9 2015).

2013

  • B Cruz-Perez, HJ Morris, J Tang, RT Hart, X Pan, and J Liu "Biaxial mechanical testing of porcine sclera using ultrasound speckle tracking for strain measurements." in American Society of Mechanical Engineering Summer Bioengineering Conference. (9 2013).

2005

  • R Xu, B Qiang and J Liu "Ultrasound-guided near-infrared spectroscopy for brain functional study: feasibility analysis and preliminary work." in SPIE. (1 2005).
  • L Cooper, J Liu, K Huang "Spatial segementation of temporal texture using mixture linear models." in International Conference of Computer Vision. (8 2005).

1999

  • Clouse, R.L.; Liu, J.; Waldron, M.B. "Recurrent spatio-temporal neuron: Advantage of potential build-up." (12 1999).
  • Liu, J.; Clouse, R.L.; Waldron, M.B. "Neuronal adaptation by varying transmission delay on recurrent excitation." (12 1999).

Patents

  • Jun Liu, Hong Chen. "Ophthalmic Elastography."
  • Jun Liu, Mauro Ferrari, Stanislav Rokhlin and Daniel Sedmak. "System and Method for Screening Tissue." Patent number: 7993271