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Mahmood Khan

  • Associate Professor, Emergency Medicine
  • 376 W 10th Ave
    760 Prior Hall
    Columbus, OH 43210
  • 614-688-7803

Honors

  • January, 2018

    Best Basic Science Presentation Award.

  • January, 2017

    Best Basic Science Presentation Award.

  • January, 2017

    Researcher of the Year.

  • November, 2016

    Fellowship of American Heart Association (FAHA).

  • November, 2016

    Best of Basic Science Poster Presenter.

  • November, 2016

    Young Investigator Award for the Top Abstract.

  • January, 2014

    Best Basic Science Presentation Award.

  • January, 2014

    Young Investigator Award.

  • January, 2013

    Best Basic Science Presentation Award.

  • January, 2013

    First Place in Scientist Category.

  • October, 2011

    Innovative Research Award.

  • May, 2010

    Early Career Investigator Travel Award.

  • October, 2008

    Poster Winner.

  • June, 2008

    Excellence Award.

  • September, 2007

    James Warren Award.

  • April, 2007

    Poster Winner.

  • October, 2006

    Finalist, Stem Cell and Myocardial Regeneraton Session, Poster Presentation.

  • September, 2005

    Young Investigator Award.

Chapters

2019

  • 2019. "Measurement of oxidative stress markers in vitro using commercially available kits." In Measuring Oxidants and Oxidative Stress in Biological Systems,

2014

  • 2014. "MicroRNAs with Mega Functions in Cardiac Repair: The Micromanagement of the Matters of the Heart." In MicroRNA in Regenerative Medicine,

2013

  • 2013. "MicroRNAs in Mesenchymal Stem Cells." In Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation, edited by Zhao, R.C.,
  • 2013. "Considerations of Quality Control Issues for the Mesenchymal Stem Cells-Based Medicinal Products." In Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation, edited by Zhao, R.C.,

2012

  • 2012. "Measurement of reactive oxygen species." In Manual of Research Techniques in Cardiovscular Medicine,

2010

  • 2010. "EPR Oximetry: Method and Application." In Methods in redox signaling,

2008

  • 2008. "Drug-induced nephrotoxicity by Spirulina." In Spirulina in Human Nutrition and Health,
  • 2008. "Spirulina - A Blue-green Alga with Novel Therapeutic Actions." In Recent Progress in Medicinal Plants,

Journal Articles

2019

  • Headley, C.A.; Gerberick, A.; Mehta, S.; Wu, Q. et al., 2019, "Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation.." Aging Cell 18, no. 3, e12926-e12926 - e12926-e12926.
  • Arunkumar, P.; Dougherty, J.A.; Weist, J.; Kumar, N. et al., 2019, "Sustained Release of Basic Fibroblast Growth Factor (bFGF) Encapsulated Polycaprolactone (PCL) Microspheres Promote Angiogenesis In Vivo.." Nanomaterials (Basel) 9, no. 7,
  • Jacob, R.; Khan, M., 2019, "Cardiac Biomarkers: What Is and What Can Be." Ind J Car Dis Wom no. 4, 240-244 - 240-244.
  • Goswami, S.K.; Ponnalagu, D.; Hussain, A.T.; Shah, K. et al., 2019, "Expression and Activation of BKCa Channels in Mice Protects Against Ischemia-Reperfusion Injury of Isolated Hearts by Modulating Mitochondrial Function." Frontiers in Cardiovascular Medicine 5, 194-194 - 194-194.
  • Singh, G.; Sridharan, D.; Khan, M.; Seshagiri, P.B., 2019, "Mouse ES-Cell Derived Cardiomyocytes Cease to Beat following Exposure to Monochromatic Light: Associated with Increased ROS and Loss of Calcium Transients." American Journal of Physiology-Cell Physiology
  • Qasim, M.; Arunkumar, P.; Powell, H.M.; Khan, M., 2019, "Current research trends and challenges in tissue engineering for mending broken hearts.." Life Sci 229, 233-250 - 233-250.

2018

  • Prabhat, A.M.; Kuppusamy, M.L.; Naidu, S.K.; Meduru, S. et al., 2018, "Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction." Frontiers in Cardiovascular Medicine 5, 114-114 - 114-114.
  • Dougherty, J.A.; Kumar, N.; Noor, M.; Angelos, M.G. et al., 2018, "Extracellular Vesicles Released by Human Induced-Pluripotent Stem Cell-Derived Cardiomyocytes Promote Angiogenesis.." Front Physiol 9, 1794 - 1794.

2017

  • Dougherty, J.A.; Kilbane Myers, J.; Khan, M.; Angelos, M.G. et al., 2017, "Dual-Specificity Phosphatase 4 Overexpression in Cells Prevents Hypoxia/Reoxygenation-Induced Apoptosis via the Upregulation of eNOS.." Front Cardiovasc Med 4, 22-22 - 22-22.
  • Dougherty, J.A.; Mergaye, M.; Kumar, N.; Chen, C.A. et al., 2017, "Potential role of exosomes in mending a broken heart: Nanoshuttles propelling future clinical therapeutics forward." Stem Cells International 2017,

2016

  • Dall, C.; Chen, C.A.; Angelos, M.G.; Khan, M., 2016, "Oxygen Cycling to Improve Survival of Stem Cells for Myocardial Repair." LIFE SCIENCES
  • Li, Z.; Fan, Z.; Xu, Y.; Lo, W. et al., 2016, "pH-Sensitive and Thermosensitive Hydrogels as Stem-Cell Carriers for Cardiac Therapy.." ACS Appl Mater Interfaces 8, no. 17, 10752-10760 - 10752-10760.

2015

  • Khan, M.; Xu, Y.; Hua, S.; Johnson, J. et al., 2015, "Evaluation of changes in morphology and function of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) cultured on an aligned-nanofiber cardiac patch." PLoS ONE 10, no. 5,
  • Dakhlallah, D.; Zhang, J.; Yu, L.; Marsh, C.B. et al., 2015, "MicroRNA-133a engineered mesenchymal stem cells augment cardiac function and cell survival in the infarct heart." Journal of Cardiovascular Pharmacology 65, no. 3, 241-251 - 241-251.
  • Angelos, M.G.; Khan, M., 2015, "CPR flow to prime the ischemic heart during cardiac arrest?." Signa Vitae 10, no. 1, 1-9 - 1-9.
  • Joddar, B.; Firstenberg, M.S.; Reen, R.K.; Varadharaj, S. et al., 2015, "Arterial Levels of Oxygen Stimulate Intimal Hyperplasia in Human Saphenous Veins via a ROS-Dependent Mechanism." PLOS ONE 10, no. 3,

2014

  • Citro, L.; Naidu, S.; Hassan, F.; Kuppusamy, M.L. et al., 2014, "Comparison of human induced pluripotent stem-cell derived cardiomyocytes with human mesenchymal stem cells following acute myocardial infarction." PloS one 9, no. 12, e116281 - e116281.

2013

  • Sherwani SI, Aldana C, Usmani S, Adin C, Kotha S, Khan M, Eubank T, Scherer P, Parinandi N, Magalang UJ., 2013, Intermittent Hypoxia Exacerbates Pancreatic β-cell Dysfunction In A Mouse Model of Diabetes Mellitus. Sleep 36, no. 12, 1849-58 - 1849-58.
  • Khan, M.; Brauner, M.E.; Plewa, M.C.; Kutala, V.K. et al., 2013, "Effect of Pulmonary-Generated Reactive Oxygen Species on Left-Ventricular Dysfunction Associated with Cardio-Pulmonary Ischemia-Reperfusion Injury." Cell Biochemistry and Biophysics
  • Khan, M.; Brauner, M.E.; Plewa, M.C.; Kutala, V.K. et al., 2013, "Effect of pulmonary-generated reactive oxygen species on left-ventricular dysfunction associated with cardio-pulmonary ischemia-reperfusion injury.." Cell Biochem Biophys 67, no. 2, 275-280 - 275-280.
  • Elnakish, M.T.; Kuppusamy, P.; Khan, M., 2013, "Stem cell transplantation as a therapy for cardiac fibrosis.." J Pathol 229, no. 2, 347-354 - 347-354.
  • Fisher, E.M.; Khan, M.; Salisbury, R.; Kuppusamy, P., 2013, "Noninvasive monitoring of small intestinal oxygen in a rat model of chronic mesenteric ischemia.." Cell Biochem Biophys 67, no. 2, 451-459 - 451-459.
  • Gogna, R.; Madan, E.; Khan, M.; Pati, U. et al., 2013, "p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.." EMBO Mol Med 5, no. 11, 1662-1683 - 1662-1683.
  • Elnakish, M.T.; Hassanain, H.H.; Janssen, P.M.; Angelos, M.G. et al., 2013, "Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: Important role of Rac/NADPH oxidase." Journal of Pathology 231, no. 3, 290-300 - 290-300.
  • Elnakish, M.T.; Molodovan, L.; Khan, M.; Hassanain, H.H. et al., 2013, "Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles.." Journal of cardiovascular pharmacology 61, no. 6,
  • Ravi, Y.; Selvendiran, K.; Meduru, S.; Citro, L. et al., 2013, "Dysregulation of PTEN in Cardiopulmonary Vascular Remodeling Induced by Pulmonary Hypertension." Cell biochemistry and biophysics 67, no. 2, 363-372 - 363-372.
  • Ravi, Y.; Selvendiran, K.; Naidu, S.K.; Meduru, S. et al., 2013, "Pulmonary hypertension secondary to left-heart failure involves peroxynitrite-induced downregulation of PTEN in the lung.." Hypertension 61, no. 3, 593-601 - 593-601.
  • Aune, S.E.; Yeh, S.T.; Kuppusamy, P.; Kuppusamy, M.L. et al., 2013, "Sivelestat attenuates myocardial reperfusion injury during brief low flow postischemic infusion.." Oxid Med Cell Longev 2013, 279847 - 279847.
  • Sun, K.; Halberg, N.; Khan, M.; Magalang, U.J. et al., 2013, "Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction.." Mol Cell Biol 33, no. 5, 904-917 - 904-917.

2012

  • Elnakish, M.T.; Hassan, F.; Dakhlallah, D.; Marsh, C.B. et al., 2012, "Mesenchymal Stem Cells for Cardiac Regeneration: Translation to Bedside Reality." Stem Cell International 2012, 646038-646038 - 646038-646038.
  • Hassan, F.; Meduru, S.; Mostafa, M.; Taguchi, K. et al., 2012, "Carvedilol enhances mesenchymal stem cell therapy for myocardial infarction via inhibition of caspase-3 expression." J PHARMACOL EXP THER 343, no. 1,
  • Elnaskish, M.; Hassona, M.; Alhaj, M.; Moldovan, L. et al., 2012, "Rac-Induced Left Ventricular Dilation and Systolic Dysfunction in Thyoxin-Treated ZmRaD Transgenic Mice: Role of Cardiomyocite Apoptosis and Myocardial Fibrosis." PLoS ONE
  • Khan, M.; Meduru, S.; Gogna, R.; Madan, E. et al., 2012, "Oxygen cycling in conjunction with stem cell transplantation induces NOS3 expression leading to attenuation of fibrosis and improved cardiac function.." Cardiovasc Res 93, no. 1, 89-99 - 89-99.

2011

  • Mundy-Bosse BL, Lesinski GB, Jaime-Ramirez AC, Benninger K, Khan M, Kuppusamy P, Guenterberg K, Kondadasula SV, Ray Chaudhury A, La Perle KM, Kreiner M, Young GS, Guttridge DC, Carson WE, 2011, "MDSC inhibition of the IFN response in tumor-bearing mice." Cancer Res
  • Nishijima, Y.; Sridhar, A.; Bonilla, I.; Velayutham, M. et al., 2011, "Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology.." Cardiovasc Res 91, no. 1, 71-79 - 71-79.
  • Elnakish, M.T.; Awad, M.M.; Hassona, M.D.H.; Alhaj, M.A. et al., 2011, "Cardiac remodeling caused by transgenic overexpression of a corn Rac gene.." Am J Physiol Heart Circ Physiol 301, no. 3, H868-H880 - H868-H880.
  • Dayton, A.; Selvendiran, K.; Meduru, S.; Khan, M. et al., 2011, "Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867.." J Pharmacol Exp Ther 339, no. 2, 350-357 - 350-357.
  • Elton, T.S.; Khan, M.; Terentyev, D., 2011, "The heart of the matter: Are miRNAs useful for tracking and treating cardiovascular disease?." Scientist 25, no. 4, 55 - 55.
  • Elnakish MY, Awad MM, Khan M, Kuppusamy P, Goldschmidt-Clermont, P, Hassanain HH et al, 2011, "Overexpression of Corn Rac Gene Induces Cardiac Hypertrophy with age in Mammalian hearts via Profilin1-induced Signaling." Am J Physiol Heart Circ Physiol EPub, EPub - EPub.
  • Khan M, Meduru S, Pandian RP, Rivera BK, Kuppusamy P, 2011, "Effect of oxygenation on stem-cell therapy for myocardial infarction." Adv Exp Med Biol 701:175-81,
  • Fisher, E.; Khan, M.; Steiner, R.; Kuppusamy, P., 2011, "Challenges to intestinal pO₂ measurement using EPR.." Adv Exp Med Biol 701, 37-44 - 37-44.
  • Mundy-Bosse, B.L.; Lesinki, G.B.; Jaime-Ramirez, A.C.; Benninger, K. et al., 2011, "Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice." Cancer Res 71, no. 15,
  • Elton, T.S.; Khan, M.; Terentyev, D., 2011, "MicroRNAs in cardiovascular disease.." F1000 Med Rep 3, 10 - 10.

2010

  • Vedam,Kaushik; Nishijima,Yoshinori; Druhan,Lawrence,J; Khan,Mahmood; Moldovan,Nicanor,I; Zweier,Jay,L; Ilangovan,Govindasamy, 2010, "Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 298, no. 6, H1832-H1841 - H1832-H1841.
  • Chacko, M.; Ahmed, S.; Selvendiran, K.; Kuppusamy, M.L. et al., 2010, "Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells." Am J Physiol Cell Physiol 299, no. 6,
  • Khan, M.; Brauner, M.E.; Plewa, M.C.; Angelos, M. et al., 2010, "Effects of Pulmonary-Generated Reactive Oxygen Species On Left Ventricular Dysfunction Associated With Ischemia-Reperfusion." Cell Biochemistry and Biophysics
  • Jayachandran, K.S.; Khan, M.; Selvendiran, K.; Devaraj, S.N. et al., 2010, "Crataegus oxycantha extract attenuates apoptotic incidence in myocardial ischemia-reperfusion injury by regulating Akt and HIF-1 signaling pathways.." J Cardiovasc Pharmacol 56, no. 5, 526-531 - 526-531.
  • Rink, C.; Roy, S.; Khan, M.; Ananth, P. et al., 2010, "Oxygen-sensitive outcomes and gene expression in acute ischemic stroke.." J Cereb Blood Flow Metab 30, no. 7, 1275-1287 - 1275-1287.
  • Swaminathan, J.K.; Khan, M.; Mohan, I.K.; Selvendiran, K. et al., 2010, "Cardioprotective properties of Crataegus oxycantha extract against ischemia-reperfusion injury.." Phytomedicine 17, no. 10, 744-752 - 744-752.
  • Khan, M.; Meduru, S.; Mostafa, M.; Khan, S. et al., 2010, "Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling.." J Pharmacol Exp Ther 333, no. 2, 421-429 - 421-429.
  • Selvendiran, K.; Kuppusamy, M.L.; Ahmed, S.; Bratasz, A. et al., 2010, "Oxygenation inhibits ovarian tumor growth by downregulating STAT3 and cyclin-D1 expressions.." Cancer Biol Ther 10, no. 4, 386-390 - 386-390.
  • Wang, F.; Li, Z.; Khan, M.; Tamama, K. et al., 2010, "Injectable, rapid gelling and highly flexible hydrogel composites as growth factor and cell carriers.." Acta Biomater 6, no. 6, 1978-1991 - 1978-1991.
  • Bognár, B.; Ahmed, S.; Kuppusamy, M.L.; Selvendiran, K. et al., 2010, "Synthesis and study of new paramagnetic and diamagnetic verapamil derivatives.." Bioorganic & medicinal chemistry 18, no. 8, 2954-2963 - 2954-2963.
  • Khan, M.; Kwiatkowski, P.; Rivera, B.K.; Kuppusamy, P., 2010, "Oxygen and oxygenation in stem-cell therapy for myocardial infarction.." Life Sci 87, no. 9-10, 269-274 - 269-274.

2009

  • Sridhar, A.; Nishijima, Y.; Terentyev, D.; Khan, M. et al., 2009, "Chronic heart failure and the substrate for atrial fibrillation.." Cardiovasc Res 84, no. 2, 227-236 - 227-236.
  • Khan M, Meduru S, Rivera B, Pandian RP, Kuppusamy ML, Kuppusamy P, 2009, "Effect of oxygenation on stem-cell therapy for myocardial infarction." Adv Exp Med Biol
  • Das, H.; George, J.C.; Joseph, M.; Das, M. et al., 2009, "Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model.." PLoS One 4, no. 10, e7325 - e7325.
  • Ryan Roberts, Eubank T, Jennifer Curry, Khan M, Periannan Kuppusamy, Clay Marsh, 2009, "GM-CSF inhibits breast cancer and metastases in mice and induces hypoxia in the tumor proper via stimulation of the soluble VEGF receptor." Cancer Res 69(5):2133- 40,
  • Mohan, I.K.; Khan, M.; Wisel, S.; Selvendiran, K. et al., 2009, "Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction.." Am J Physiol Heart Circ Physiol 296, no. 1, H140-H151 - H140-H151.
  • Khan, M.; Meduru, S.; Mohan, I.K.; Kuppusamy, M.L. et al., 2009, "Hyperbaric oxygenation enhances transplanted cell graft and functional recovery in the infarct heart.." J Mol Cell Cardiol 47, no. 2, 275-287 - 275-287.
  • Khan,Mahmood; Mohan,Iyyapu,K; Kutala,Vijay,K; Kotha,Sainath,R; Parinandi,Narasimham,L; Hamlin,Robert,L; Kuppusamy,Periannan, 2009, "Sulfaphenazole Protects Heart Against Ischemia-Reperfusion Injury and Cardiac Dysfunction by Overexpression of iNOS, Leading to Enhancement of Nitric Oxide Bioavailability and Tissue Oxygenation." ANTIOXIDANTS & REDOX SIGNALING 11, no. 4, 725-738 - 725-738.
  • Chacko M, Khan M, Kuppusamy et al, 2009, "Monitoring of tissue oxygenation and functional improvement in a rat model of acute myocardial infarction (AMI) treated with stem cells." Am J Physiol Heart Circ Physiol 296(5):H1263-73,
  • Eubank, T.D.; Roberts, R.D.; Khan, M.; Curry, J.M. et al., 2009, "Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages.." Cancer Res 69, no. 5, 2133-2140 - 2133-2140.
  • Wisel, S.; Khan, M.; Kuppusamy, M.L.; Mohan, I.K. et al., 2009, "Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression.." J Pharmacol Exp Ther 329, no. 2, 543-550 - 543-550.
  • Chacko, S.M.; Khan, M.; Kuppusamy, M.L.; Pandian, R.P. et al., 2009, "Myocardial oxygenation and functional recovery in infarct rat hearts transplanted with mesenchymal stem cells.." Am J Physiol Heart Circ Physiol 296, no. 5, H1263-H1273 - H1263-H1273.

2008

  • Khan M, Kutala VK, Wisel S, Chacko SM, Kuppusamy ML, Kwiatkowski P and Kuppusamy P, 2008, "Measurement of myocardial tissue pO2 after stem cell therapy using oxygen sensing probe by EPR spectroscopy." Adv Exp Med Biol 614:45-52,

2007

  • Wisel,Sheik; Chacko,Simi,M; Kuppusamy,M,Lakshmi; Pandian,Ramasamy,P; Khan,Mahmood; Kutala,Vijay,Kumar; Burry,Richard,W; Sun,Benjamin; Kwiatkowski,Pawel; Kuppusamy,Periannan, 2007, "Labeling of skeletal myoblasts with a novel oxygen-sensing spin probe for noninvasive monitoring of in situ oxygenation and cell therapy in heart." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 292, no. 3, H1254-H1261 - H1254-H1261.
  • Kutala, V.K.; Khan, M.; Angelos, M.G.; Kuppusamy, P., 2007, "Role of Oxygen in Post-ischemic Myocardial Injury." Antioxi Red Signal 9, no. 8, 1193-1206 - 1193-1206.
  • Khan, M.; Kutala, V.K.; Vikram, D.S.; Wisel, S. et al., 2007, "Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function.." Am J Physiol Heart Circ Physiol 293, no. 4, H2129-H2139 - H2129-H2139.
  • Khan, M.; Mohan, I.K.; Kutala, V.K.; Kumbala, D. et al., 2007, "Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen species.." J Pharmacol Exp Ther 323, no. 3, 813-821 - 813-821.
  • Mandal, R.; Kutala, V.K.; Khan, M.; Mohan, I.K. et al., 2007, "N-hydroxy-pyrroline modification of verapamil exhibits antioxidant protection of the heart against ischemia/reperfusion-induced cardiac dysfunction without compromising its calcium antagonistic activity.." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 323, no. 1,

2006

  • 30. Khan M, Kutala VK, Vikram D, Wisel S, Pawel Kwiatkowski, Simi M Chacko, Kuppusamy ML, Jay L Zweier and Kuppusamy P, 2006, "Non-invasive Tracking of Cells and Monitoring of In Situ pO2 during Engraftment of Skeletal Myoblasts in Infarct Mouse Heart." Circulation. Vol 114, No 18,
  • Khan,M; Varadharaj,S; Shobha,J,C; Naidu,M,U; Parinandi,N,L; Kutala,V,K; Kuppusamy,P, 2006, "C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes." Journal of Cardiovascular Pharmacology 47, no. 1, 9-20 - 9-20.
  • Sridhar, A.; Nishijima, Y.; Hamlin, R.L.; Cames, C.A., 2006, "Atrial ionic remodeling in chronic non-ischemic heart failure." CIRCULATION 114, no. 18, 199-199 - 199-199.
  • Khan, M.; Varadharaj, S.; Ganesan, L.P.; Shobha, J.C. et al., 2006, "C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling.." Am J Physiol Heart Circ Physiol 290, no. 5, H2136-H2145 - H2136-H2145.
  • Kutala, V.K.; Khan, M.; Mandal, R.; Potaraju, V. et al., 2006, "Prevention of postischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and Tempol.." J Cardiovasc Pharmacol 48, no. 3, 79-87 - 79-87.
  • Khan, M.; Shobha, J.C.; Mohan, I.K.; Rao Naidu, M.U. et al., 2006, "Spirulina attenuates cyclosporine-induced nephrotoxicity in rats.." J Appl Toxicol 26, no. 5, 444-451 - 444-451.
  • Kumar KV, Khan M, Rajarsi Mandal, Latha P. Ganesan, Susheela Tridandapani, Tamas Kalai, Kalman Hideg, and Periannan Kuppusamy, 2006, "Attenuation of Myocardial Ischemia-reperfusion Injury by Trimetazidine Derivatives Functionalized with Antioxidant Properties." Journal of Pharmacology and Experimental Therapeutics 317, no. 3, 921-928 - 921-928.
  • Kálai, T.; Khan, M.; Balog, M.; Kutala, V.K. et al., 2006, "Structure-activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia-reperfusion injury.." Bioorg Med Chem 14, no. 16, 5510-5516 - 5510-5516.
  • Mohan, I.K.; Khan, M.; Shobha, J.C.; Naidu, M.U.R. et al., 2006, "Protection against cisplatin-induced nephrotoxicity by Spirulina in rats.." Cancer Chemother Pharmacol 58, no. 6, 802-808 - 802-808.
  • Mohan, I.K.; Kumar, K.V.; Naidu, M.U.R.; Khan, M. et al., 2006, "Protective effect of CardiPro against doxorubicin-induced cardiotoxicity in mice.." Phytomedicine 13, no. 4, 222-229 - 222-229.

2005

  • Khan, M.; Shobha, J.C.; Mohan, I.K.; Naidu, M.U.R. et al., 2005, "Protective effect of Spirulina against doxorubicin-induced cardiotoxicity.." Phytother Res 19, no. 12, 1030-1037 - 1030-1037.

2004

  • Khan, M. Patil, P. A. Shobha, J. C., 2004, "Influence of Bryophyllum pinnatum (Lam.) leaf extract on wound healing in albino rats." Journal of natural remedies l 4: 41-46,

Presentations

  • "Hyperbaric oxygenation enhances the stem cell graft and improves the functional recovery in the infarct heart." 2008, Presented at 3rd Annual DHLRI retreat,
  • "Role of Oxygenation and Stem Cells for Myocardial Regeneration." 2011, Presented at Seminar for Students and Faculty,
  • "Stem-cell Therapy for Cardiac Repair: Challenges and Approaches." 2009, Presented at Fourth Annual Research Day, Davis Heart and Lung Research Institute,
  • "Reprogramming of Stem Cells by miRNAs." 2012, Presented at International Conference on Stem Cells and Regenerative Medicine,
  • "Antioxidant activity of Spirulina extract in-vitro." 2002, Presented at Thirty-Fifth Annual Conference of the Indian Pharmacological Society,
  • "Influence of Bryophyllum Pinnatum Lam on wound healing in albino rats." 2002, Presented at Thirty-Fourth Annual Conference of the Indian Pharmacological Society,
  • "C-phycocyanin improves cardiac dysfunction by attenuating oxidative stress and inhibition of p38 MAPK activity in isolated rat heart subjected to ischemia-reperfusion." Presented at Free Radical Biology and Medicine,
  • "C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult cardiomyocytes in vitro.." Presented at Free Radical Biology and Medicine,
  • "Attenuation of ischemia-reperfusion injury In hearts by trimetazidine derivatives functionalized with antioxidant properties.." Presented at Free Radical Biology and Medicine,
  • "Non-Invasive Measuerment of Myocardial Oxygenation in the Infarct Heart After Stem Cell Therpy." 2007, Presented at Society for Free Radical Research,
  • "Effect of spirulina on cyclosporine–induced nephrotoxicity in rats.." 2004, Presented at International Symposium on Recent Advances in Pharmacology,
  • "Sulfaphenazole Protects Heart Against Ischemia-reperfusion Injury and Cardiac Dysfunction by Overexpressin of iNOS Leading to Enhancement of Nitric-Oxide Bioavailability and Tissue Oxygen." Presented at Third Annual DHLRI Retreat,
  • "Increased expression of heat shock protein 25 in doxorubicin-treated failing hearts." Presented at 4th Annual Symposium of the American-Heart-Association-Council on Basic Cardiovascular Sciences,
  • "Hyperbaric oxygen enhances the Engraftment and survival of Mesenchymal stem cells in the infarct heart." 2008, Presented at 3rd Annual DHLRI retreat,
  • "Hyperbaric oxygenation enhances the stem cell graft and improves the functional recovery in the infarct heart." 2009, Presented at International Society on Oxygen Transport to Tissue Meeting,
  • "Trimetazidne (Vastarel) Protects Mesenchymal Stem Cell against Oxidative Stress and Enhances Cell Therapy in Infarct Rat Heart by Activation of Akt and Bcl-2 Expression." 2008, Presented at 3rd Annual DHLRI retreat,
  • "Sulfaphenazole, a cytochrome P450 inhibitor attenuates ischemia-reperfusion injury through involvement of iNOS, AKT and p38 MAPK in a rat model of myocardial infarction." 2007, Presented at American Heart Association,
  • "Non-invasive Tracking of Cells and Monitoring of In Situ pO2 during Engraftment of Skeletal Myoblasts in Infarct Mouse Heart.." Presented at American Heart Association,
  • "Mir-133 Transfection in MSCs Downregulates Critical Pro- Apoptotic Genes in the Infarct Heart and Improves Cardiac Function." 2011, Presented at American Heart Association Scientific Sessions,
  • "Stem Cell Therapy for Cardiac Repair." 2010, Presented at Society for Free Radical Research Meeting,
  • "Novel cell-based therapies for mending broken hearts." 2017, Presented at Wright State University,
  • "Stem cells for myocardial repair: Challenges and approaches." 2015, Presented at University of Cincinatti,
  • "Stem cells in myocardial regeneration." 2012, Presented at University of Minnesota,
  • "Stem Cell Therapy for Cardiac Repair." 2010, Presented at Society for Free Radical Research,
  • "Bioengineering of Nanofiber Cardiac Patch for Myocardial Repair." 2015, Presented at H3C Health Science and Innovation Conference,
  • "Regenerative Medicine." 2015, Presented at H3C Health Science and Innovation Conference,
  • "Stem Cell and Regenerative Medicine: Research to Business." 2012, Presented at Stem Cells in Cardiac Disease, International School of Business,
  • "Session Chair: US-JSPS Electron Paramagnetic Resonance Core-to-Core Symposium." 2008, Presented at US-JSPS Electron Paramagnetic Resonance Core-to-Core Symposium,
  • "GM-CSF inhibits breast cancer and metastases in mice and induces hypoxia in the tumor proper via stimulation of the soluble VEGF receptor." 2007, Presented at Davis Heart and Lung Research Institute 2nd Annual Research Retreat,
  • "Stem Cells in Mending Broken Hearts." 2019, Presented at University of Alabama,
  • "Bioengineering Scaffolds for Cardiac Tissue Engineering." 2018, Presented at University of Kansas,
  • "Cellular and Cell-free Therapeutics for Myocardial Repair." 2017, Presented at University of Nebraska,
  • "Stem Cells of Myocardial Repair." 2017, Presented at Indians Institute of Technology (IIT, Hyderabad),
  • "Current Trends in Myocardial Repair and Regeneration." 2017, Presented at Indian Institute of Technology (IIT, Mumbia),
  • "Basic and Therapeutics Applications of Pluripotent Stem Cells." 2017, Presented at Global Initiative on Academic Network (GIAN),
  • "Sulfaphenazole and Cardioprotection: Modulation of Myocardial Oxygenation, iNOS and Akt in Rat Model Acute of Myocardial Infarction." 2008, Presented at US-JSPS Core-to-Core Electron Paramagnetic Resonance Symposium,
  • "Bioengineering scaffolds for cardiac regeneration. Stem cells for myocardial repair: Challenges and approaches." 2017, Presented at Wright State University,

Papers in Proceedings

2017

  • Khan, M.; Dougherty, J.; Angelos, M.G.; Chen, C-A. "Modulation of p53 by DUSP4 Serves a Novel Therapeutic Strategy in the Treatment of Ischemic Heart Disease via Promoting Angiogenesis." in 24th Annual Meeting of the Society-for-Redox-Biology-and-Medicine (SfRBM). (11 2017).
  • Dougherty, J.; Mergaye, M.; Chun-An, C.; Angelos, M.G. et al. "Exosomes Isolated From Human Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Enhance Angiogenesis in-vitro; a New Potential Therapy for the Post-Ischemic Heart." in Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. (11 2017).

2016

  • Khan, M.; Johnson, J.; Angelos, M.G. "Biodegradable Multilayered Aligned Nanofiber Cardiac Patch Composed of Human Inducible Pluripotent Stem Cell Derived Cardiomyocytes (hiPSC-CMs) Enhances Cardiac Function and Cell Survival In Vivo." in Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. (11 2016).

2012

  • Elnakish, M.T.; Hassona, M.D.H.; Alhaj, M.A.; Moldovan, L. et al. "Physiologic Cardiac Hypertrophy and Cardiac Dilation: A Comparative Study Using ZmRacD Transgenic Mouse Model." in Experimental Biology Meeting. (4 2012).

2011

  • Khan,Mahmood; Meduru,Sarath; Pandian,Ramasamy,P; Rivera,Brian,K; Kuppusamy,Periannan "Effect of Oxygenation on Stem-Cell Therapy for Myocardial Infarction." in 37th Annual Meeting of the International-Society-on-Oxygen-Transport-to-Tissue. (1 2011).
  • Khan, M.; Meduru, S.; Bryant, A.; Martin, M. et al. "Mir-133 Transfection in Mscs Downregulates Critical Pro-Apoptotic Genes in the Infarct Heart and Improves Cardiac Function." (11 2011).
  • Elnakish, M.T.; Hassona, M.D.H.; Awad, M.M.; Abouelnaga, Z.A. et al. "Over-expression of a Corn Rac Gene Induces Cardiac Hypertrophy in Old Transgenic Mice: a Putative Role of Profilin1-Induced Signaling." (4 2011).

2010

  • Mundy, B.L.; Lesinski, G.; Benninger, K.; Khan, M. et al. "Myeloid-derived Suppressor Cells and Decreased Interferon Responsiveness in Tumor-Bearing Mice." (10 2010).

2008

  • Khan, M.; Wisel, S.; Lyyapu, K.M.; Lakshmi, M. et al. "Hyperbaric Oxygen Therapy Enchances the Survival and Engraftment of Mesenchymal Stem Cells in the Infarct Heart." in 15th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine. (1 2008).

2007

  • Angelos, M.G.; Khan, M.; Aune, S.E.; Clanton, T.L. et al. "Controlled myocardial tissue reoxygenation (PO2) with low flow reperfusion improves post ischemic LV function." (10 2007).
  • Moldovan, N.I.; Butt, O.; Alzawhra, W.; Khan, M. et al. "Composition of bone marrow-derived progenitor cells in the cellular infiltrate of infareted hearts: Role of local oxygen tension." in Experimental Biology 2007 Annual Meeting. (4 2007).

2006

  • Khan, M.; Kutala, V.K.; Vikram, D.; Wisel, S. et al. "Non-invasive monitoring of in situ oxygenation and engraftment of skeletal myoblasts transplanted in ischemic mouse heart." (1 2006).