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Joshua Englert

  • Physician, FGP-Pulm, Crit Care, & Sleep
  • Assistant Professor, Pulmonary, Crit Care, & Sleep
  • 473 W 12th Ave
    Columbus, OH 43210

Honors

  • January, 2018

    BAL Award.

  • January, 2017

    Outstanding Young Investigator Award.

  • January, 2016

    K Travel Award.

  • January, 2014

    Young Physician Scientist Award.

  • January, 2014

    Chair's Research Award.

  • January, 2012-
    January, 2014

    Loan Repayment Award.

  • January, 2014

    Grant Review and Support Program.

  • January, 2009-
    January, 2011

    Loan Repayment Award.

  • January, 2007

    Nominee, Best Resident Teacher Award.

  • January, 2005

    Brinton Prize.

  • January, 2004-
    December, 2004

    Alpha Omega Alpha.

  • January, 2004

    Academy of Achievement Summit.

  • January, 2001-
    January, 2003

    Robert and Gertrude Harris Foundation Scholarship.

  • January, 1999-
    December, 1999

    Ruth E. Duffy Scholarship.

  • January, 1999

    Research Experience for Undergraduates (REU) Fellow.

  • January, 1998

    Alpha Epsilon Delta.

Chapters

2017

  • 2017. "Sepsis Syndrome." In The Brigham Intensive Review of Internal Medicine,
  • 2017. "Mechanical Ventilation." In The Brigham Intensive Review,

2012

  • Sing, A.J.; Loscalzo, J.. 2012. "Sepsis syndrome.." In The Brigham Intensive Review of Internal Medicine,

2008

  • 2008. "Sepsis syndrome.." In Brigham Intensive Review of Internal Medicine,

Journal Articles

2019

  • Chung, S.; Kim, J.Y.; Song, M-A.; Park, G.Y. et al., 2019, "FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma.." Allergy 74, no. 3, 535-548 - 535-548.

2018

  • Englert, J.A.; Christman, J.W.; Ballinger, M.N., 2018, "Unhinging the machinery of sepsis: An unexpected role for vascular smooth muscle." Journal of Leukocyte Biology
  • Hume, P.S.; Varon, J.; Englert, J.A.; Hurwitz, S. et al., 2018, "Trends in “usual care” for septic shock." Infection Control and Hospital Epidemiology 1-2 - 1-2.
  • Hay, B.R.; Shilo, K.; Englert, J.A., 2018, "Bilateral lung masses and dyspnea in a young woman." Annals of the American Thoracic Society 15, no. 7, 875-879 - 875-879.
  • Casey, J.D.; Englert, J.A.; Katz, J.T.; Miller, A.L. et al., 2018, "An unexpected expectoration." New England Journal of Medicine 378, no. 9, 853-858 - 853-858.

2017

  • Putman, R.K.; Hunninghake, G.M.; Dieffenbach, P.B.; Barragan-Bradford, D. et al., 2017, "Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome.." Am J Respir Crit Care Med 195, no. 1, 138-141 - 138-141.
  • Englert, J.A.; Crouser, E.D., 2017, "Steroids and β-Agonists in acute respiratory distress syndrome: Timing is everything." Critical Care Medicine 45, no. 5, 914-915 - 914-915.
  • Ghanta, S.; Tsoyi, K.; Liu, X.; Nakahira, K. et al., 2017, "Mesenchymal stromal cells deficient in autophagy proteins are susceptible to oxidative injury and mitochondrial dysfunction." American Journal of Respiratory Cell and Molecular Biology 56, no. 3, 300-309 - 300-309.
  • Hepokoski, M.; Englert, J.A.; Baron, R.M.; Crotty-Alexander, L.E. et al., 2017, "Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney." American Journal of Physiology - Renal Physiology 312, no. 4, F654-F660 - F654-F660.

2016

  • Hou, H.W.; Wu, L.; Amador-Munoz, D.P.; Vera, M.P. et al., 2016, "Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy." Lab on a Chip - Miniaturisation for Chemistry and Biology 16, no. 4, 688-699 - 688-699.
  • Englert, J.A.; Rogers, A.J., 2016, "Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis." Clinics in Chest Medicine 37, no. 2, 321-331 - 321-331.

2015

  • Englert,Joshua,A; Macias,Alvaro,A; Amador-Munoz,Diana; Vera,Miguel,Pinilla; Isabelle,Colleen; Guan,Jiazhen; Magaoay,Brady; Velandia,Margarita,Suarez; Coronata,Anna; Lee,Awapuhi; Fredenburgh,Laura,E; Culley,Deborah,J; Crosby,Gregory; Baron,Rebecca,M, 2015, "Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity." ANESTHESIOLOGY 123, no. 2, 377-388 - 377-388.

2014

  • Haspel,Jeffrey,A; Chettimada,Sukrutha; Shaik,Rahamthulla,S; Chu,Jen-Hwa; Raby,Benjamin,A; Cernadas,Manuela; Carey,Vincent; Process,Vanessa; Hunninghake,G,Matthew; Ifedigbo,Emeka; Lederer,James,A; Englert,Joshua; Pelton,Ashley; Coronata,Anna; Fredenburgh,Laura,E; Choi,Augustine,MK, 2014, "Circadian rhythm reprogramming during lung inflammation." NATURE COMMUNICATIONS 5, 4753 - 4753.

2012

  • Lai,Peggy,S; Fresco,Jennifer,M; Pinilla,Miguel,A; Macias,Alvaro,A; Brown,Ronald,D; Englert,Joshua,A; Hofmann,Oliver; Lederer,James,A; Hide,Winston; Christiani,David,C; Cernadas,Manuela; Baron,Rebecca,M, 2012, "Chronic Endotoxin Exposure Produces Airflow Obstruction and Lung Dendritic Cell Expansion." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 47, no. 2, 209-217 - 209-217.

2011

  • Fredenburgh,Laura,E; Velandia,Margarita,MSuarez; Ma,Jun; Olszak,Torsten; Cernadas,Manuela; Englert,Joshua,A; Chung,Su,Wol; Liu,Xiaoli; Begay,Cynthia; Padera,Robert,F; Blumberg,Richard,S; Walsh,Stephen,R; Baron,Rebecca,M; Perrella,Mark,A, 2011, "Cyclooxygenase-2 Deficiency Leads to Intestinal Barrier Dysfunction and Increased Mortality during Polymicrobial Sepsis." JOURNAL OF IMMUNOLOGY 187, no. 10, 5255-5267 - 5255-5267.
  • Haspel,Jeffrey; Shaik,Rahamthulla,S; Ifedigbo,Emeka; Nakahira,Kiichi; Dolinay,Tamas; Englert,Joshua,A; Choi,Augustine,MK, 2011, "Characterization of macroautophagic flux in vivo using a leupeptin-based assay." AUTOPHAGY 7, no. 6, 629-642 - 629-642.
  • Nakahira,Kiichi; Haspel,Jeffrey,Adam; Rathinam,Vijay,AK; Lee,Seon-Jin; Dolinay,Tamas; Lam,Hilaire,C; Englert,Joshua,A; Rabinovitch,Marlene; Cernadas,Manuela; Kim,Hong,Pyo; Fitzgerald,Katherine,A; Ryter,Stefan,W; Choi,Augustine,MK, 2011, "Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome." NATURE IMMUNOLOGY 12, no. 3, 222-U57 - 222-U57.

2006

  • Yang,Runkuan; Harada,Tomoyuki; Mollen,Kevin,P; Prince,Jose,M; Levy,Ryan,M; Englert,Joshua,A; Gallowitsch-Puerta,Margot; Yang,LiHong; Yang,Huan; Tracey,Kevin,J; Harbrecht,Brian,G; Billiar,Timothy,R; Fink,Mitchell,P, 2006, "Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock." MOLECULAR MEDICINE 12, no. 4-6, 105-114 - 105-114.
  • Killeen,M,E; Englert,J,A; Stolz,D,B; Song,M,C; Han,Y,S; Delude,R,L; Kellum,J,A; Fink,M,P, 2006, "The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 316, no. 3, 1070-1079 - 1070-1079.

2005

  • Yang,R,K; Harada,T; Li,J,Y; Uchiyama,T; Han,Y,S; Englert,J,A; Fink,M,P, 2005, "Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism." INTENSIVE CARE MEDICINE 31, no. 5, 709-717 - 709-717.
  • Han,Y,S; Englert,J,A; Yang,R,K; Delude,R,L; Fink,M,P, 2005, "Ethyl pyruvate inhibits nuclear factor-kappa B-dependent signaling by directly targeting p65." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 312, no. 3, 1097-1105 - 1097-1105.
  • Han,Y,S; Englert,J,A; Delude,R,L; Fink,M,P, 2005, "Ethacrynic acid inhibits multiple steps in the NF-kappa B signaling pathway." SHOCK 23, no. 1, 45-53 - 45-53.
  • Sappington,P,L; Cruz,R,J; Harada,T; Yang,R,K; Han,Y,S; Englert,J,A; Ajami,A,A; Killeen,M,E; Delude,R,L; Fink,M,P, 2005, "The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro." BIOCHEMICAL PHARMACOLOGY 70, no. 11, 1579-1592 - 1579-1592.
  • Englert, J., 2005, "The multiple organ dysfunction syndrome and late-phase mortality in sepsis.." Current infectious disease reports 7, no. 5,

Presentations

  • "Role of NOS-2 in a mouse model of sepsis induced ARDS." 2009, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Role of mechanical mTORC1 activation in ventilator induced lung injury." 2015, Presented at Invited Research Seminar,
  • "Role of mTORC1 activation in the pathogenesis of stretch induced lung injury." 2011, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Role of surfactant protein D in polymicrobial sepsis." 2013, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Zinc deficiency primes the lung for ventilator induced lung injury." Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "mTORC1 activation and impaired autophagy in ventilator induced lung injury." 2010, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Zinc, mechanical ventilation, and ARDS." 2016, Presented at Pulmonary Research Conference,
  • "ARDS, From clinical observations to translational studies." 2017, Presented at Pulmonary Research Conference,
  • "Targeting mechanotransduction in the lung to develop novel ARDs therapies." 2018, Presented at Center for Perinatal Research Seminar,
  • "Role of mTORC1 activation in ventilator induced lung injury and the acute respiratory distress syndrome." 2017, Presented at Central Society for Clinical and Translational Research Annual Meeting,
  • "Navigating Early Career Funding." 2017, Presented at American Thoracic Society International Conference,

Papers in Proceedings

2017

  • Putman, R.K.; Hunninghake, G.M.; Dieffenbach, P.B.; Barragan-Bradford, D. et al. "Interstitial lung abnormalities are associated with acute respiratory distress syndrome." (1 2017).

2016

  • Englert, J.A.; Cho, M.H.; Lamb, A.; Shumyatcher, M. et al. "Whole Blood Rna Sequencing In Stem Cell Transplant Patients With The Acute Respiratory Distress Syndrome Reveals A Unique Transcriptomic Profile." (1 2016).
  • Abdulai, R.; Englert, J.A. "Sarcoid-Associated With Mgus: An Atypical Presentation." (1 2016).
  • Hepokoski, M.; Englert, J.A.; Baron, R.; Crotty-Alexander, L. et al. "Renal Angiopoietin-2 Is Increased After Injurious Mechanical Ventilation In A Murine Model Of Sepsis." (1 2016).

2015

  • Englert, J.A.; Isabelle, C.; Henske, E.P.; Choi, A.M.K. et al. "Mtorc1 Is Activated In Airway Epithelial Cells In A Murine Vili Model And Following In Vitro Stretch." (1 2015).

2014

  • Englert, J.A.; Vera, M.A.P.; Castano, A.P.; Perrella, M.A. et al. "Survival After Cecal Ligation And Puncture In Surfactant Protein D Deficient Mice Is Dependent Upon Gut Microbial Flora." (1 2014).
  • Cornonata, A.; Englert, J.A.; Lederer, J.; Choi, A.M.K. et al. "Circadian Rhythm Disruption Via Bmal1 Deletion Increases Sepsis Severity." (1 2014).

2013

  • Englert, J.A.; Macias, A.A.; Pinilla-Vera, M.A.; Guan, J. et al. "Inhaled Isoflurane Ameliorates Acute Lung Injury By Preserving Epithelial Tight Junction Integrity." (1 2013).

2011

  • Lai, P.S.; Austin, J.M.; Brown, R.D.; Macias, A.A. et al. "Airway Reactivity And Persistent Inflammation Is Associated With Antigen Presenting Cell Population Shifts In A Murine Model Of Chronic Inhalational Endotoxin Exposure." (1 2011).

2009

  • Englert, J.A.; Ma, J.; Perrella, M.A.; Fredenburgh, L.E. "COX-2 Deficiency Leads to Increased Intestinal Epithelial Permeability during Peritonitis-Induced Polymicrobial Sepsis." (1 2009).
  • Englert, J.A.; Lopez, S.; Riascos, D.F.; Dolgonos, L. et al. "Increased NOS2 Expression in a Clinically-Relevant Murine Model of ARDS." (1 2009).
  • Austin, J.M.; Englert, J.A.; Riascos, D.F.; Brown, R.D. et al. "Modeling Physiologic Effects of Chronic Endotoxin Exposure in Mice." (1 2009).

2004

  • Englert, J.A.; Han, Y.; Fink, M.P. "Ethacrynic acid (EA) inhibits release of NO2-, TNF, and IL-6 by LPS-stimulated RAW 264.7." (1 2004).

2001

  • Englert, J.A.; Matchett, S.C.; Baker, K.; Wasser, T. et al. "Impact of a blood transfusion protocol for non-bleeding patients in the intensive care unit." (12 2001).