BME Seminar Series: Dr. Tatiana Segura, Duke

All dates for this event occur in the past.

ZOOM
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United States

Tatiana Segura, PhD
Professor
Department of Biomedical Engineering
Duke

Abstract: 

"Biomaterials to unlock the regenerative capacity of tissues" 

Injectable materials that can conform to the shape of a desired space are used in a variety of fields including medicine. The ability to fill a tissue defect with an injectable material can be used for example to deliver drugs, augment tissue volume, or promote repair of an injury. This talk will explore the development of injectable materials that are based on assembled particle building blocks, for tissue repair. We find that using microparticle building blocks to build the scaffold generates a porous network by the space left behind between adjacent building blocks. Due to the injectability of this microporous material we have explored its wide applicability to tissue repair applications ranging from skin to brain wounds. In this talk, I will describe how MAP scaffolds can modulate the wound healing immune response and lead to regenerative wound healing.

Bio: 

Dr. Tatiana Segura, Professor of Biomedical Engineering, Neurology and Dermatology at Duke University. She received her BS degree in Bioengineering from the University of California Berkeley and her doctorate in Chemical Engineering from Northwestern University. She joined Jeffrey A. Hubbell’s laboratory as an F32 Ruth L. Kirschstein National Research Service Award. In 2006 she joined the Chemical and Biomolecular Engineering Department at University of California Los Angeles as a tenure track Assistant Professor, a position she secured in 2004 before beginning her postdoctoral appointment. In 2012 she received tenure and was promoted to Associate Professor. In 2016 she was promoted to the title of Professor.  She joined the Duke faculty in 2018.

Prof. Segura’s laboratory is highly multidisciplinary, with researchers from backgrounds in basic and applied sciences and medicine, working on cutting edge approaches to promote endogenous repair with biomaterials. She balances the investigation of basic cell-material interactions with the design of translatable biomaterials strategies to promote endogenous repair. Prof. Segura’s work has been instrumental in our understanding of how biomaterial design impacts the repair of new blood vessels and axonal sprouting in the brain after stroke and how our immune system can be leveraged to promote the regeneration of skin wounds. Her research in porous scaffolds lead to the co-discovery of microporous annealed particle (MAP) scaffolds, which are injectable porous materials that promote rapid cellular infiltration. MAP scaffolds have been widely adopted in the biomaterials field and are being pursued for translation and FDA approval. Prof. Segura is a co-founder of Tempo Therapeutics, which seeks to commercialize MAP technology.  

Segura has received numerous awards and distinctions during her career. Most recently she received the 2021 Acta Biomaterialia Silver Medal Award. She also received a CAREER Award from the National Science Foundation, an Outstanding Young Investigator Award from the American Society of Gene and Cell Therapy a National Scientist Development Grant from the American Heart Association and was also named a Fellow of the American Institute for Medical and Biological Engineers in 2017. Prof. Segura has published over 150 peer reviewed papers and reviews and has over 6,000 citations.